Knee, Osteoarthritis, Pathogenesis, Prevalence. Root cause of disease Primary osteoarthritis has no known cause. Secondary osteoarthritis is caused by another disease, infection, injury, or deformity. Osteoarthritis starts with the breakdown of cartilage in the joint. As the cartilage wears down, the bone ends may thicken and form bony growths (spurs). Symptoms Causes Home Remedies to…